Abstract: The boron enriched layers of Paleoproterozoic Liaohe group exist in the study area. In order to determine the distribution of boron mineralization, geochemical and geophysical survey is carried out in the known structural alteration belts. With analysis of the geochemical and geophysical characteristics of boron mineralization, combined with the metallogenic geological conditions, the geological and geophysical-geochemical prospecting model for this area is established. It is believed that the anticlinorium and synclinorium of Lieryu Formation, Liaohe group are related to the boron mineralization. The physic-chemical characteristics of boron mineralization in the area are as follows:The ground magnetic field values are distributed as high magnetic field. Gradient IP survey shows low resistivity and high amplitude frequency. Electrical sounding inversion resistivity indicates low-resistance linear structural belt and high IP anomalous zone. The resistance is relatively low where the mineralization is strong. The geochemical anomaly is dominated by boron, with an obvious concentration center, associated with lead, zinc and silver composite geochemical anomalies.