Abstract: In view of the problem of low grade copper and zinc , the good floatability of zinc mineral and the difficult in separation of copper and zinc in tailings somewhere in Hunan , the test adopted the process of copper -zinc mixed flotation -flotation separation of copper -zinc mixed concen-trate.Copper-zinc flotation separation used lime , zinc sulfate and sodium sulfite as the inhibitors of zinc sulfur minerals , and diethyldithiocarbamate as the collector of copper mineral , which real-ized the effective separation of copper -zinc minerals , as well as the maximum utilization of re-sources .Through closed-circuit experiment the copper concentrate with the grade of 17 .94%and the recovery of 61 .47% and the zinc concentrate with the grade of 45 .43% and the recovery of 59 .73%were obtained respectively .This process provided the technical direction for the reasona -ble development of this type of copper -zinc ore, at the same time put forward the effective recover-y approach of low-grade copper zinc mine of the tailings .