Abstract: With the exploitation of copper resources at home and abroad,the ore grade is lower and lower,and it is more difficult to deal with complex copper mine,which makes the traditional copper smelting process bring many problems such as low efficiency and serious pollution.In smelting process,arsenic is often scattered in the roasting or smelting of each product,deteriorating blister copper quality,affecting sulfuric acid production,polluting atmosphere and poisoning the environment.To explore reasonable copper and arsenic separation method in high arsenic copper,the paper carried on experimental study on pressure leaching for high arsenic copper concentrate,and the influences of liquid-solid ratio,temperature,oxygen partial pressure and residence time on extracting rate of Cu and As were investigated.Results show that under the optimal condition the leaching rate of copper is over 99%,and the fixing arsenic rate is 60%.