In general, the fine grid model constructed from the reservoir description stage contains more than one millions grids.However, it is not possible to import the fine grid to a traditional simulator directly.On the basis of previous research, a relative rapid and efficient method of upscaling is proposed in this paper.The proposed method, in which the anisotropy of permeability can be considered, is based on the heterogeneity DP (Dykstra-Parsons)coefficient and upper and lower permeability limits (C_min, C_max).The computational performance of the method is much faster than the traditional upscaling technique.The fine 3D geological model of Chang 6 layer of the Yanchang Formation in the central Ordos basin was calculated by the proposed method.The reservoir simulation was performed on the coarse grids. Furthermore, according to the geological setting of the study area and the low compressibility of the fluids and rocks, a numerical simulation study of the reservoir was conducted on the fine geological model by using the streamline simulator, and then the effectiveness of the upscaling method for a period of time was evaluated systematically with the results of the study as the standard.The contrast of results indicates that not only the computational performance of the proposed method is much faster, but also the results of the method are reliable.The proposed method provides an efficient technique for resolving the highly accurate simulation of strongly heterogeneous, complex reservoirs of continental origin.