Abstract: This paper targets its research at the exploitation–reinjection well of geothermal fluid of one geothermal heating project in Tianjin, China, examines such factors as ground temperature, CO2 partial pressure and stratum lithology, and simulates the changes in the main component contents of geothermal fluids mixed at different proportions in the exploitation and reinjection well. The research findings show that the mixed fluids are increasingly similar in nature to the reinjected water as the reinjection process goes on. It’s suggested that the manual method should be used to ensure the reinjected water has the similar mineralization as the exploited ground water in the process of reinjection and some acceptable adjustments should be made according to the specific component and water temperature. The study on water-rock balance calculation shows that PHREEQC can simulate the complicated chemical reactions related to water when the transfer of solute happens, so the necessary technological supports are given for the reasonable development and protection of geothermal resources.