Abstract: Through the measurement of soil profile, soil mercury gas and rock profile in the outskirts of the Dingjiashan ore district and the re-establishment of the geological and geochemical exploration model, the authors made the metallogenic prediction in the depth and outskirts of the ore district. The results show that there exist obvious Hg, Ag, Au soil anomalies and soil mercury gas anomalies as well as heat-released mercury anomalies, which are evidently in close relation to the Yanshanian intrusive dykes, intrusions and mineralization of granodiorite porphyry, with quartz diorite porphyry being the dominant mechanism of the anomalies. A comparison with the Chengmenshan ore district shows that there exist good metallogenic prospects in the depth and outskirts of the Dingjiashan ore district. It should be noted that silver-gold mineralization in Silurian sandstone is likely to be found at the periphery of the Dingjiashan ore district whereas molybdenum (copper) mineralization might be found in the depth (-500 to -1000 m).