Abstract: The Xinjiang-Gansu-Inner Mongolia juncture area is divided into two parts, i.e., Xingxingxia-Hanshan micro-plant and Dunhuang micro-plant, and the suture line between them is Hongliuhe-Niujuanzi-Xichangjing ophiolite belt. Paleozoic tectonic evolution of the area underwent three stages: Sinian-Ordovician belonged to the old landmass divergence and ocean basin spreading stage, Silurian-Devonian belonged to the plate subduction and collision-orogeny stage, and Carboniferous-Permian belonged to the continental rift stage. In Cambrian, the shallow marine basin of old landmass was divergent frequently, and sedimentary deposits could be formed, such as phosphorus-vanadium-uranium-manganese mineral resources. In Ordovician ocean basin and back-arc basin, volcano-sedimentary type copper-zinc minerals could be formed, and Silurian-Devonian island-arc volcanic formation might serve as host rock of porphyry copper deposits. The volcano-sedimentary type iron deposits probably occurred in Carboniferous-Permian continental rift sedimentary formation, and porphyry copper deposits and copper-nickel deposits of basic rock type could be formed. The palaeocontinunt crust melting type granite mass constituted favorable background for the formation of metallogenic W, Sn and rare metal deposits.