Abstract: The obvious multi-stage mineralization related to the Mesozoic crust-mantle magmatism is strong in Guangdong region. On the basis of previous work, the deposits related to the Mesozoic magmatism can be divided into six metallogenic series in terms of metallogenic ages, tectonic environment, main process and deposit associations, namely, 1) Nb, Ta, P and Fe deposits related to Indosinian magmatism in Yunkai area; 2) nonferrous, rare, precious metals, nonmetal and U deposits related to Yanshanian granites in northern Guangdong depression; 3) Cu, Pb, Zn, Au, Fe, Mo, W, As, V, Ti, crystal and ferrous sulfide deposits related to Yanshanian intermediate acid-basic intrusive rocks along deep fault zones; 4) Au and Ag deposits related to regional, dynamic metamorphism and Yanshanian granites; 5) Fe, Cu, Au, Ag, Pb, Zn, W, Sn, Mo, Nb, Ta, ferrous sulfide, crystal, fluorite, pyrophyllite and barite deposits related to Yanshanian volcanic-intrusive activity in coastal region; and 6) Sn, W, Mo, Cu, Fe, Pb, Zn and Ag deposits in Yangchun-Luoding area related to Late Yanshanian crust-source granites. The basic characteristics and forming tectonic backgrounds of each metallogenic series are discussed followed by the temporal and spatial distribution and evolution law of mineralization.