Abstract: Ecological quality is an important indicator of a regional development level. Objective, quantitative dynamic monitoring and analysis of long-term ecological quality can provide a scientific basis for urban sustainable development and ecological construction. Based on Landsat remote sensing images, this study constructed the remote sensing ecological index (RSEI) as an evaluation index using principal component analysis. Accordingly, this study explored the spatiotemporal change characteristics of ecological quality in Zhengzhou from 2001 to 2020, as well as the extent of influence of various driving factors, using the Sen+Mann-Kendall trend analysis, the Hurst index, and geographical detectors. The results indicate that from 2001 to 2020, Zhengzhou maintained moderate ecological quality overall. The RSEI showed downward, upward, and then downward trends sequentially. Spatially, the eastern plains showed lower ecological quality, whereas the southwestern mountainous and hilly areas exhibited higher ecological quality. The regional ecological quality remained unchanged predominantly or saw slight improvements over these years except for 2010, when the area of zones with ecological quality deteriorating significantly increased due to high temperature. From 2001 to 2020, the ecological quality in Zhengzhou exhibited significant trends, with 56.34% of areas showing an upward trend and 42.26% exhibiting a downward trend. These results, along with the Hurst index, reveal that the downward trend in ecological quality in the eastern part is primarily characterized by sustainable changes in the future, while the upward trend in ecological quality in the southwestern partition is primarily characterized by anti-sustainable changes in the future. Driving force analysis indicates that over the 20 years, primary factors influencing changes in ecological quality in Zhengzhou included land use type and population density, whose explanatory power is significantly stronger than other factors. The impact of natural factors, such as elevation and average annual precipitation, has gradually diminished, while the influence of the night light index, which reflects the urbanization level, has progressively increased. The results of this study will provide a scientific basis for the evaluation and preservation of ecosystems in Zhengzhou.