Abstract: Shaanxi Province, serving as both one of China’s initial pilot areas for the returning farmland to forestland/grassland project and an important energy supply base in the Yellow River basin, has made substantial investments in mineral resource development and ecological environment protection and restoration in recent years. Based on trend analysis and correlation analysis conducted using MATLAB, this study examined the spatiotemporal differentiation pattern of vegetation ecology and its responses to the dual disturbances of climate conditions and mining activities. The results indicate that from 2001 to 2022, the normalized difference vegetation index (NDVI) of Shaanxi Province exhibited an upward trend while fluctuating, with an average annual increase of 0.006. The lowest NDVI value occurred in 2015. Precipitation acted as the major factor affecting the NDVI of Shaanxi Province. In most areas, NDVI exhibited a significant positive correlation with both precipitation and humidity. The correlation between NDVI and mining activities was increasingly significant with an increase in the mining area. In some energy-based cities, NDVI decreased initially and then increased, exhibiting a V-shaped trend. Overall, mining activity made more positive than negative contributions to changes in NDVI of Shaanxi Province. The results of this study will provide foundational data and a scientific reference for ecological protection and mine restoration and management in Shaanxi Province.