Abstract: The process mineralogy of a low-grade copper-gold ore in Australia shows that copper in ore exists as Chalcopyrite, most of gold exists as monomeric native gold between sulfide and gangue particles, and some of it is enclosed by pyrite in the form of invisible gold. The average particle size of chalcopyrite and pyrite is 0.03 mm. The copper concentrate with copper 19.02% and gold grade 13.99 g/t, recovery of copper 73.00% and gold 49.29% was obtained by copper and gold bulk flotation. Through the regrinding and gold leaching of sulfur concentrate, the gold leaching rate for raw ore is 14.92%, the total gold recovery is 64.21%, and the sulfur grade of leaching residue is 30.23%, which can be sold as a sulfur concentrate.