Abstract: The definition of avoidance distance between deposition hole and water conducting fracture is an important basis for evaluating the site suitability of the high-level waste disposal repository, and it is also one of the key contents of the design of high-level waste disposal repository. In this paper, the site of the Beishan underground research laboratory is taken as the reference site for geological disposal of high-level radioactive waste. This paper established a computational model for the release and migration of radionuclides after closure of repository by GoldSim. Then, the avoidance distance between deposition hole and water conducting fracture in intact rock was analyzed by the method of Monte Carlo stochastic simulation. The results show that a 80% hydraulic conductivity value of the granite in the study area is less than 1.0×10^-9 m/s under the existing conditions, and when the hydraulic conductivity value of water conduction fracture is set to 1.0×10^-6 m/s, the corresponding avoidance distance is less than 0.5 m. The smaller the permeability coefficient is, the smaller the corresponding safety avoidance distance is. The analysis of the results shows that the avoidance distance between the deposition hole and water conducting fracture can provide a feedback guidance for the site selection and design of the disposal repository.