Abstract: the Central-South Qilian Area consist of two metallogenic belts: Central Qilian and South Qilian. There are 13 metallogenic series and 28 metallogenic subseries of mineral deposits in the metallogenic belt of Central Qilian, and 12 metallogenic series and 23 metallogenic subseries of mineral deposits in the metallogenic belt of South Qilian. Based on these metallogenic series of mineral deposits, the metallogenic pedigree in the Central-South of Qilian area was established. According to these metallogenic subseries of mineral deposits, the refined regional metallogenic pedigrees of the two belts were established. The regional metallogenic evolution history was summarized in sequence from Precambriam, Early Paleozoic, Neopaleozoic, Mesozoic to Cenozoic. In order to help readers not only understand the regional metallogenic evolution regulation, but also can query concrete deposits which they are interested in, a lot of deposit examples which related to sedimentation, magmatism, metamorphism and supergenesis are enumerated in this article.